Dr. M.C.E.F. Wijffels

Werkzaam op locatie Nieuwegein

Opleiding tot arts
1985-1991 MD degree (Cum Laude), Medical Faculty, University of Maastricht.

Opleiding tot medisch specialist
2002-2003 Fellowship Clinical Cardiac Electrophysiology, Department of Cardiology, Academic Hospital Maastricht.

1998-2000 Resident Internal Medicine, Academic Hospital Maastricht (Prof. H. Hillen).

1997 Lorex Synthélabo Cardiology Award (Dutch Society of Cardiology), 1st prize thesis 1996.
Hamburger Award (Dutch Society of Physiology), 1st prize thesis 1996.

1996-2003  Resident Cardiology, Academic Hospital Maastricht  (Prof. H. Wellens and Prof. H. Crijns).

1996 PhD degree (Cum Laude) Thesis: ”Atrial Fibrillation Begets Atrial Fibrillation”.

1995-1996 CARIM Dissertation Award (Cardiovascular Research Institute Maastricht), 1st prize thesis.

1992-1996  Research fellow, department of Physiology, University of Maastricht.

MRM Jongbloed, MCEF Wijffels , MJ Schalij, NA Blom, RE Poelmann, A van der Laarse, MMT Mentink, Z Wang, GI Fishman, AC Gittenberger-de Groot. Development of the Right Ventricular Inflow Tract and Moderator Band; A Possible Morphological and Functional Explanation for Mahaim Tachycardia. Circ Res 2005;96:776-783.

Zeppenfeld K , Kies P , Wijffels MC EF , Bootsma M , van Erven L , Schalij MJ . Identification of Successful Catheter Ablation Sites in Patients with Ventricular Tachycardia Based on Electrogram Characteristics during Sinus Rhythm. Heart Rhythm 2005;2:940-950.

MCEF Wijffels. Geeft Paroxismaal Atriumfibrilleren Meer Risico op Trombo-embolie-vorming (en CVA) dan Continu Atriumfibrilleren? Hoe Zit het met de Indicatie Antistolling versus Ascal®? Cardiologen Vademecum 2006;9(1).

NM de Groot, K Zeppenfeld, MCEF Wijffels , WK Chan, NA Blom, WK Chan, EE Van der Wall, MJ Schalij. Ablation of Focal Atrial Arrhythmia in Patients with Congenital Defects after Surgery: Role of Circumscribed Areas with Heterogeneous Conduction. Heart Rhythm 2006;3:526-535.

P Kies, M Bootsma, JJ Bax, K Zeppenfeld, L van Erven, MCEF Wijffels , EE van der Wall, MJ Schalij. Serial Reevaluation of ARVD/C is Indicated in Patients Presenting with Left Bundle Branch Block Ventricular Tachycardia and Minor ECG Abnormalities. J Cardiovasc Electrophysiology 2006;17:586-593.

C Ypenburg, L van Erven, G Bleeker, JJ Bax, M Bootsma, MCEF Wijffels , EE van der Wall, MJ Schalij. Benefit of Combined Resynchronization and Defibrillator Therapy in Heart Failure Patients with and without Ventricular Arrhythmias. J Am Coll Cardiol 2006;48:464-470.

I Eralp, H Lie-Venema, NAM Bax, MCEF Wijffels , A van der Laarse, MC DeRuiter, AJJC Bogers, NMS van den Akker, RG Gourdie, MJ Schalij, RE Poelmann, AC Gittenberger-de Groot. Epicardium-Derived Cells are Important for Correct Development of the Purkinje Fibers in the Avian Heart. The Anatomical Record 2006;288A:1272-1280.

DP Kolditz, MCEF Wijffels , NA Blom, A van der Laarse, RR Markwald, MJ Schalij, AC Gittenberger-de Groot. Persistence of Functional Atrioventricular Accessory Pathways in Post-Septated Embryonic Avian Hearts: Implications for Morphogenesis and Functional Maturation of the Cardiac Conduction System. Circulation 2007;115:17-26.

AC Gittenberger-de Groot, EAF Mahtab, ND Hahurij, LJ Wisse, MC DeRuiter, MCEF Wijffels , RE Poelmann. Nkx2.5-Negative Myocardium of the Posterior Heart Field and Its Correlation with Podoplanin Expression in Cells from the Developing Cardiac Pacemaking and Conduction System. The Anatomical Record 2007;290:115-122

MCEF Wijffels , CCMM Timmermans, RJ van Suylen, LM Rodriguez. Internal Atrial Shock Delivery by Standard Diagnostic Electrophysiology Catheters in Goats. Effects on Atrial Electrogram Amplitude and Tissue Architecture. Accepted Europace 2007.

MCEF Wijffels. Levert Paroxismaal Atriumfibrilleren Meer Risico op Trombo-embolie-vorming dan Continu Atriumfibrilleren? Cardiologen Vademecum 2007;X(X).

DP Kolditz, MCEF Wijffels , NA Blom, A van der Laarse, ND Hahurij, H Lie-Venema, RR Markwald, RE Poelmann, MJ Schalij, AC Gittenberger-de Groot.Epicardium-Derived-Cells in Development of Annulus Fibrosis and Persistence of Accessory Pathways. Circulation 2008;117:1508-1517.

EAF Mahtab, MCEF Wijffels , NM van den Akker, ND Hahurij, H Lie-Venema, LJ Wisse, MC DeRuiter, P Urin, J Zuajec, BR Binder, MJ Schalij, RE Poelmann, AC Gittenberger-de Groot. Cardiac Malformations and Myocardial Abnormalities in Podoplanin Knockout Mouse Embryos: Correlation with Abnormal Epicardial Development. Dev Dyn 237;847-857.

H Lie-Venema, I Eralp, RR Markwald, NM van den Akker, MCEF Wijffels , DP Kolditz, A van der Laarse, MJ Schalij, RE Poelmann, AJJC Bogers, AC Gittenberger-de Groot. Periostin expression by epicardium-derived cells (EPDCs) is involved in the development of the atrioventricular valves and fibrous heart skeleton. Differentiation 2008;76:809-19.

Van de Veire NR, Marsan NA, Schuijf JD, Bleeker GB, Wijffels MCEF , van Erven L, Holman ER, De Sutter J, van der Wall EE, Schalij MJ, Bax JJ. Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomography and noninvasive assessment of left ventricular dyssynchrony by 3-dimensional tissue synchronization imaging in patients with heart failure scheduled for cardiac resynchronization therapy. Am J Cardiol 2008;101:1023-9.

Boersma LV, Wijffels MCEF , Oral H, Wever EF, Morady F. Pulmonary vein isolation by duty-cycled bipolar and unipolar radiofrequency energy with a multielectrode ablation catheter. Heart Rhythm 2008;5:1635-42.

MCEF Wijffels . De Relatie tussen het Oppervlakte ECG en Intracardiale Afleidingen. In Gorgels APM, Smeets JLRM (eds): Leerboek Elektrocardiologie. Houten, The Netherlands, Bohn, Stafleu van Loghum 2005, pp 11-26.